R65.1Header code — not billable

Systemic inflammatory response syndrome (SIRS) of non-infectious origin

Short description: SIRS of non-infectious origin

Chapter
18. Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified
Category
R65
Effective date
October 1, 2026

Related codes in category R65

R65Symp and signs specifically assoc w sys inflam and infctR65.10SIRS of non-infectious origin w/o acute organ dysfunctionYesR65.11SIRS of non-infectious origin w acute organ dysfunctionYesR65.2Severe sepsisR65.20Severe sepsis without septic shockYesR65.21Severe sepsis with septic shockYes

Frequently asked questions

What is ICD-10 code R65.1?

R65.1 is an ICD-10-CM diagnosis code for Systemic inflammatory response syndrome (SIRS) of non-infectious origin.

Is R65.1 a billable code?

No. R65.1 is a category/header code, not billable on its own — use one of its more specific child codes instead.

What ICD-10-CM chapter is R65.1 in?

R65.1 falls under Chapter 18: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified.

When did R65.1 become effective?

R65.1 has been effective since October 1, 2026, per the CMS/CDC ICD-10-CM annual release.

What other codes are related to R65.1?

R65.1 belongs to category R65, which includes 6 other codes — see the related codes list on this page.

ICD-10-CM data maintained by CDC/CMS (public domain). Always verify codes with authoritative sources before making coding or billing decisions.