R65Header code — not billable

Symptoms and signs specifically associated with systemic inflammation and infection

Short description: Symp and signs specifically assoc w sys inflam and infct

Chapter
18. Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified
Category
R65
Effective date
October 1, 2026

Related codes in category R65

R65.1SIRS of non-infectious originR65.10SIRS of non-infectious origin w/o acute organ dysfunctionYesR65.11SIRS of non-infectious origin w acute organ dysfunctionYesR65.2Severe sepsisR65.20Severe sepsis without septic shockYesR65.21Severe sepsis with septic shockYes

Frequently asked questions

What is ICD-10 code R65?

R65 is an ICD-10-CM diagnosis code for Symptoms and signs specifically associated with systemic inflammation and infection.

Is R65 a billable code?

No. R65 is a category/header code, not billable on its own — use one of its more specific child codes instead.

What ICD-10-CM chapter is R65 in?

R65 falls under Chapter 18: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified.

When did R65 become effective?

R65 has been effective since October 1, 2026, per the CMS/CDC ICD-10-CM annual release.

What other codes are related to R65?

R65 belongs to category R65, which includes 6 other codes — see the related codes list on this page.

ICD-10-CM data maintained by CDC/CMS (public domain). Always verify codes with authoritative sources before making coding or billing decisions.