E88.81Header code — not billable
Metabolic syndrome and other insulin resistance
- Chapter
- 4. Endocrine, nutritional and metabolic diseases
- Category
- E88
- Effective date
- October 1, 2026
Related codes in category E88
E88Other and unspecified metabolic disordersE88.0Disorders of plasma-protein metabolism, NECE88.01Alpha-1-antitrypsin deficiencyYesE88.02Plasminogen deficiencyYesE88.09Oth disorders of plasma-protein metabolism, NECYesE88.1Lipodystrophy, not elsewhere classifiedE88.10Lipodystrophy, unspecifiedYesE88.11Partial lipodystrophyYesE88.12Generalized lipodystrophyYesE88.13Localized lipodystrophyYesE88.14HIV-associated lipodystrophyYesE88.19Other lipodystrophy, not elsewhere classifiedYes
Frequently asked questions
What is ICD-10 code E88.81?
E88.81 is an ICD-10-CM diagnosis code for Metabolic syndrome and other insulin resistance.
Is E88.81 a billable code?
No. E88.81 is a category/header code, not billable on its own — use one of its more specific child codes instead.
What ICD-10-CM chapter is E88.81 in?
E88.81 falls under Chapter 4: Endocrine, nutritional and metabolic diseases.
When did E88.81 become effective?
E88.81 has been effective since October 1, 2026, per the CMS/CDC ICD-10-CM annual release.
What other codes are related to E88.81?
E88.81 belongs to category E88, which includes 12 other codes — see the related codes list on this page.
ICD-10-CM data maintained by CDC/CMS (public domain). Always verify codes with authoritative sources before making coding or billing decisions.