D57.21Header code — not billable
Sickle-cell/Hb-C disease with crisis
- Chapter
- 3. Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
- Category
- D57
- Effective date
- October 1, 2026
Related codes in category D57
D57Sickle-cell disordersD57.0Hb-SS disease with crisisD57.00Hb-SS disease with crisis, unspecifiedYesD57.01Hb-SS disease with acute chest syndromeYesD57.02Hb-SS disease with splenic sequestrationYesD57.03Hb-SS disease with cerebral vascular involvementYesD57.04Hb-SS disease with dactylitisYesD57.09Hb-SS disease with crisis with other specified complicationYesD57.1Sickle-cell disease without crisisYesD57.2Sickle-cell/Hb-C diseaseD57.20Sickle-cell/Hb-C disease without crisisYesD57.211Sickle-cell/Hb-C disease with acute chest syndromeYes
Frequently asked questions
What is ICD-10 code D57.21?
D57.21 is an ICD-10-CM diagnosis code for Sickle-cell/Hb-C disease with crisis.
Is D57.21 a billable code?
No. D57.21 is a category/header code, not billable on its own — use one of its more specific child codes instead.
What ICD-10-CM chapter is D57.21 in?
D57.21 falls under Chapter 3: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism.
When did D57.21 become effective?
D57.21 has been effective since October 1, 2026, per the CMS/CDC ICD-10-CM annual release.
What other codes are related to D57.21?
D57.21 belongs to category D57, which includes 12 other codes — see the related codes list on this page.
ICD-10-CM data maintained by CDC/CMS (public domain). Always verify codes with authoritative sources before making coding or billing decisions.